A CDC/NIOSH-authored 2025 study found that sanding boron-nitride-nanotube epoxy composites released respirable particulate; collected dust caused dose-dependent cytotoxicity, reduced live human macrophage counts, mixed pyroptosis and apoptosis, and increased intracellular reactive oxygen species in vitro. The authors describe these results as an initial hazard characterization rather than evidence of disease in exposed people.
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Collected respirable BNNT epoxy sanding dust exposure ... caused dose-dependent increase in cytotoxicity ... a 10–15% decrease in live cell count due to mixed pyroptosis and apoptosis in human macrophages. A dose-dependent increase in intracellular reactive oxygen species ... was also observed.