The UK HSE review states that carmine causes occupational asthma in some exposed workers, reports positive bronchial-challenge results, and classifies it as a respiratory sensitiser under its reviewed criteria.
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page 13 · C2: CARMINE — Summary and conclusion · 1
page 13 · C2: CARMINE — Summary and conclusion · 1
Carmine, which is an insect-derived dyestuff, causes occupational asthma in some exposed workers, and a total of 10 positive bronchial challenge test results are available. The mechanism appears to be immunological, and there is evidence that the allergen is not the dye molecule carminic acid, but a high molecular weight component of the preparation.