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Dust entry

Piperazine dust

Dust from anhydrous piperazine and related pharmaceutical or industrial powder handling.

Airborne form

dust

The form describes what is suspended in air at the point of exposure. A material can produce more than one form, such as dust during handling and fume during heating.

Health effects

occupational asthma concernrespiratory sensitizationbronchoconstriction concernskin and eye irritation concern

Evidence

The UK HSE review associates occupational asthma with piperazine use, particularly flaking dusty anhydrous piperazine, reports asthma symptoms among exposed workers, and classifies piperazine as a respiratory sensitiser under its reviewed criteria.

Source: pdf ↗ · saved source
page 71 · C23: PIPERAZINE — Summary and conclusion · 1
The use of piperazine has been associated with the development of asthma in the workplace, and some limited positive bronchial challenge data are available. The finding that specific immunoglobulin E (IgE) has been found in about half of those with symptoms, but rarely occurs in exposed, asymptomatic individuals, suggests an immunological basis for the asthma.

Controls