NIOSH Current Intelligence Bulletin 70 states that the silver REL for total silver (metal dust, fume, and soluble compounds) is intended to prevent argyria and concludes that silver nanoparticles should be considered a respiratory hazard in occupational settings.
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page 1 · Summary; Recommendations · 2NIOSH continues to recommend a REL of 10 µg/m3 as an 8-hour TWA for total silver (metal dust, fume, and soluble compounds, as Ag). The REL and IDLH for total silver are based on preventing workers from developing argyria.
NIOSH lists blue-gray discoloration of the eyes, nasal septum, throat, and skin; skin irritation and ulceration; and gastrointestinal disturbance among symptoms associated with silver dust and soluble compounds.
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Exposure Limits; Exposure Routes; Symptoms; Target Organs · 1NIOSH REL TWA 0.01 mg/m³. OSHA PEL TWA 0.01 mg/m³. Exposure Routes inhalation, ingestion, skin and/or eye contact. Symptoms Blue-gray eyes, nasal septum, throat, skin; irritation, ulceration skin; gastrointestinal disturbance. Target Organs Nasal septum, skin, eyes.